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A computational study for mockling class I MHC binding peptides

  • The role accomlished by Major Histocompatibility Complex (MHC) molecules in initiating and regulating immune respouses, binding short pepticles and displaying them on the cell surface for recoguition by Tiell receptors, is of the atmost importance in immunlogogy. However, only a subset of peptider is capable of binding to any particular MHC molecule. The study was undertaken to rationalize MHC/ peptide interactions in terms of molecular structural requirements for the prediction of class I MHC buding peptides. Prediction of buding activities by means of computational methods can minimize experimental assays, and lead to the development of vaceines and immune-therapeutie drugs.

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Author:Simonetta Fickel
Advisor:Gunter Krautheim
Document Type:Diploma Thesis
Language:English
Date of Publication (online):2003/07/08
Year of first Publication:2001
Date of final exam:2001/05/15
Tag:MHC binding molecules; QSAR; binding profile; hydrophobic moment
GND Keyword:Simulation
Page Number:61 Seiten, 30 Abb., 11 Tab., 18 Lit.
Faculty:Westsächsische Hochschule Zwickau / Physikalische Technik, Informatik
Release Date:2003/07/08