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The here presented work is about the development of an atom pair descriptor based virtual screening system. In the beginning the fundamentals are explained which are the base of the following chapters. The chemical data file formats, the term descriptor as well as the enrichment factor and the process of benchmarking is discussed. In the main part the development of the virtual screening system is explained and afterwards the results on the bcr-abl kinase target protein are interpreted. For the development of the virtual screening system the realization of the atom pair descriptor, the different similarity methods and their selection is discussed. Also the clustering and the functio-nality of the virtual screening system are explained. Afterwards the results of the bcr-abl kinase screening are discussed and the functionality of the virtual screening system is evaluated. Finally a conclusion is given where set goals and achieved outcomes are compared and an outlook for possible future projects is presented.