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The role accomlished by Major Histocompatibility Complex (MHC) molecules in initiating and regulating immune respouses, binding short pepticles and displaying them on the cell surface for recoguition by Tiell receptors, is of the atmost importance in immunlogogy. However, only a subset of peptider is capable of binding to any particular MHC molecule. The study was undertaken to rationalize MHC/ peptide interactions in terms of molecular structural requirements for the prediction of class I MHC buding peptides. Prediction of buding activities by means of computational methods can minimize experimental assays, and lead to the development of vaceines and immune-therapeutie drugs.