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The role accomlished by Major Histocompatibility Complex (MHC) molecules in initiating and regulating immune respouses, binding short pepticles and displaying them on the cell surface for recoguition by Tiell receptors, is of the atmost importance in immunlogogy. However, only a subset of peptider is capable of binding to any particular MHC molecule. The study was undertaken to rationalize MHC/ peptide interactions in terms of molecular structural requirements for the prediction of class I MHC buding peptides. Prediction of buding activities by means of computational methods can minimize experimental assays, and lead to the development of vaceines and immune-therapeutie drugs.
BIM (Building information modeling) is becoming a reliable method for the planning, design, implementation, and maintenance stages of construction projects due to its ability to improve the quality of project stages, reduce project time, and ensure costs. From 2000 onwards, the trend of using BIM method increased in the world. And in the last decade, many developed countries have introduced BIM as a reasonable and efficient method with the aim of optimizing project stages, and many employers have paid attention to training and persuading consulting and contracting companies.
In the meantime, the BIM method is constantly being updated. Many researchers are looking to modify existing sub-methods to help the project achieve all of the great BIM goals.
Although BIM has great goals such as those mentioned, in some cases, projects are not able to achieve all of them for various reasons.
This thesis has put its hypothesis on the existence of deficiencies in the content of the EIR (Employer's Information Requirements) document and its writing methods.
This document, which is a kind of project guide in BIM format, is compiled by the client and its task is to announce the needs of the client to the members involved in the project and to clarify the different stages of the project. In many construction projects, due to the complexity of the EIR, the employer's lack of attention to some information, or the failure to include the opinions and views of the project's stakeholders in the writing of this document, the EIR cannot fulfill its key role with its maximum potential performance in the project.
This thesis is written with the aim of finding a comprehensive solution to maximize the power of the BIM method in a project through correct and complete document writing.
Also, this thesis seeks to prove its claims by focusing on the ABS 38 project as a case study. In addition, a literature review on important and key issues in the field of BIM and EIR documents has been done. After that, a scoring system (Relative rating method) was used to find the best variant and compare it to prove the proposed hypothesis.
Since Carbon emissions are soaring all over the atmosphere, the world suffers from significant problems daily. It has become apparent that reliance on single occupancy vehicle transportation is unsustainable, expensive, and primarily harmful to humankind. Rural areas are frequently abandoned while expanding
transportation infrastructure as urbanisation grows. In rural areas, a lack of adequate and inexpensive transportation options leads to seclusion and restricted access to products, facilities, and job opportunities.
This study explores the potential of alternative transportation methods to improve mobility in rural areas. The objectives of the research are to expand knowledge on sustainable alternative transportation in rural regions and to offer practical solutions for enhancing accessibility and mobility for rural residents.
The study employed a mixed-method approach, including a literature review, a survey, and interviews with participants in two rural regions, Mosel and Oberrothenbach. The findings suggest that the transportation challenges faced by rural inhabitants can be effectively and sustainably addressed through walking and by using alternative transportation modes, such as cycling and public transit. This thesis provides a range of ideas and strategies to improve regulations, programs, and infrastructure related to alternative transportation modes in rural areas. This study dives into the characteristics and requirements
of these places using a combination of quantitative and qualitative surveys done in representative two rural regions to recommend successful alternative transportation solutions of On-Demand Transport Services and Electric or Trolley bus Services for daily commutes. The findings underline the need for flexible, multimodal, and on-demand transit choices, as well as the need for community participation and technology integration.
Despite lacking sufficient evidence, the shift to automated mobility has often been regarded as progress towards a safer road transport system. Following the introduction of the first production car that has been officially certified as Level 3 earlier in 2022, the driver can shift their role to only as a fallback when the automated driving system reaches its limit of the Operational Design Domain. In the event of an accident, though, the matter will only get even more complicated, especially in the process of unravelling the party that was performing the Dynamic Driving Task at the time of the collision. An accident investigation is done to provide insight into how it occurred and uncover the liable parties. This thesis reviews various methods reconstructing an accident scene, such as photogrammetry and laser scanning, as well as elaborating the relevant data that has already available in the vehicle and from the infrastructure. Recommendations are also presented on for the future data collection, specifically in the scenario of automated driving, to improve such practice.
Active Traffic Management Systems – Developing a Package of Measurements for the City of Füssen
(2021)
Intelligent Transportation Systems (ITS) and Active Transportation and Demand Management (ATDM) are new commanders in the world of transportation engineering. The combination of ATDM and ITS has created a concept called “Active Traffic Management (ATM)”. The world’s ATM is getting a higher point for major technological changes that have been bringing new ways in public and private transport managing, decision making, smart cities, traffic control, safety and environment.
The management, control, influence of travel demand and traffic flow in transportation facilities is referred to as ATM. Actions are taken in real time to improve system performance, such as preventing or delaying breakdown conditions, enhancing safety, encouraging sustainable travel modes or cutting emissions, using archived data and or/predictive methods.
In this Master's thesis, it has been exanimated the prominent different areas of Active Traffic Management in traffic engineering with a special focus on the sections of traffic management, signal control, and simulations with the program VISSIM. To discuss this issue, this paper begins with a brief introduction of the names and concepts of the current technologies in ATM, followed by an example. Important data and challenges for the study case of the city of Füssen in Germany will be presented in the text, subsequent to some results, conclusions and recommendations. In addition, the current and alternative scenarios with their respective level of service are researched according to German regulations. A simulation of different nodes has been modeled to observe the respective delays, level of services and emissions of the intersections selected in the city.
Keywords
Traffic Engineering, Intelligent Transportation Systems (ITS), Active Traffic Management (ATM), Level of Service (LOS) and Traffic Simulation.
As one of the key technologies involved in communication networks, all-optical switching has witnessed many research efforts during the last decade. This work presents a detailed investigation of the properties and attractive interaction of spatial solitons in nematic liquid crystals for all-optical switching devices. This includes a description of basic properties such as their multimode behavior, as well as their power dependent interactions and signal steering. Furthermore, the temporal performance of an all-optical switching setup is analyzed and discussed. Thanks to their long-range, phase and wavelength independent interactions at milliwatts powers, and despite their slow response time in switching applications, nematicons proved to be an extremely promising testbed for soliton-based devices, including signal waveguides and power-dependent spatial steering devices.
The use of fossil resources must be phased out during the next decades in order to stay below a well below 2°C trajectory adopted with the Paris Agreement. The growing threat of climate changes arises large uncertainties concerning natural and social systems and induced changes on economic activities and human welfare in the 21st century. As recent climate negotiations failed to achieve significant progress to stop the climate change, GHG emissions fragmented the international communities. Total carbon dioxide (CO2) concentration is at the highest levels ever recorded. Since, it is very important to differentiate the total CO2 and its origin.
Evidently, CO2 has been identifed as the most important GHG because it contributes the largest share to the anthropogenic increase of radiative forcing and grows fastest. Anthropogenic sources of CO2 emissions are fossilfuel combustion (FFC), cement production, traditional biomass combustion and land use change, which contain chlorouorocarbons, hydrochlorouorocarbons and others. Where Biogenic CO2 emission sources are fermentation, biogas and other biological process. Compare to atropogenicsource with high purity.
The thesis provides an improved overview of R&D, pilot, demonstration and commercial projects that capture CO2 from biogas plants and other biogenic sources and subsequently put this carbon to further use. Best practices in terms of business models and GHG saving potentials are described. The CO2 emissions mitigation are related to the innovation, technologies, investment and moreover the strong policies from the Government
With the launch of a new vehicle model Rolls-Royce Motorcars had to face a dramatic volume increase from 300% more cars being build in existing structure and facilities in the Test and Finish Area. This massive volume increase required a revisiting of the process flow of cars through this Test and Finish Area to show optimisation potential and possible improvements to work packages and sequence of operation. Furthermore it will be necessary to implement those improvements to cope increased future throughput targets. To find optimisation and improvement potentials it was essential to analyse the entire area. In doing so every single station and work package was analysed. In addition to this a simulation model was used to confirm the highlighted problems and bottlenecks. Furthermore it was possible to investigate the influence of certain measures. In a following step it was the aim to show a way how a permanent and stable vehicle flow is achievable. According to that an action plan was developed, which shows clear measures to cope not only future but also the current production volume. In doing so it was possible to gain a transparency into the processes. Furthermore the process flow was optimised into a pull strategy to improve respectively implement a takt adherence.
Analysis of Traffic Management using Microscopic Simulation and Markov chain Modeling in Hyderabad
(2022)
Many developing countries around the world have been affected by globalization. India is one of the countries that has gained the most benefits. Hyderabad is the capital of the Indian state of Telangana. Because of population growth and the migration of people from rural to urban areas, traffic in Hyderabad is rapidly expanding. With commercial enterprise quarters, purchasing departmental stores, schools, and hospitals, Hyderabad has evolved into a financial hub. As a result, the number of people who own and use automobiles is increasing. Traffic congestion and regular traffic jams have become widespread in central areas, as they have traffic gridlocks on major corridors. The majority of the city’s transportation needs are currently met by bus transit (42 percent), the Multimodal Transport System (MMTS) based on the rail (1.5 percent), vehicles with three and seven seats (8 percent), and two and four-wheeled private automobiles (48.5 percent). Hyderabad is located at a crossroads of three national highways that connect it to six other states. The primary purpose of this article is to understand the city’s existing traffic challenges, find solutions that have been effectively adopted in established cities, and discuss the many projects and actions undertaken by local authorities to manage traffic congestion issues.
Traffic congestion can occur in any mode of transportation, but we focused on traffic congestion on the road network caused by vehicles. Lower velocity, lengthier travels, and car queuing for an extended period are some of the characteristics that distinguish street networks. In this paper, the causes of traffic congestion are identified, including illegal parking, traffic rules, seasonal factors, pavement failures, encroaching on footpaths, the passage of heavy goods vehicles on narrow roads, accidents, and incorrect lane management, as well as remedial measures to reduce congestion at the study location of Hyderabad.
The thesis analysis the car parks’ elements and the factors that influence the drivers’ behaviour on them. Then makes an approach to the definition of the strategy of how the car drivers search for free parking spaces. The reason for it is that there is a need to assess car parks’ design parameters in the terms of their performance. One of the decisive factors is also the drivers’ behaviour. A car park simulation based on the environment of matrices is designed and implemented in MATLAB. The algorithm for searching for the parking spaces is designed and implemented within that as well. The results of the simulation are presented.
The traffic calming measures aim to slow down traffic speed, accident frequency, and reduction of through traffic caused mainly by motorized vehicles in residential areas. These measures are primarily addressed to the specific streets and lead the necessary or remaining traffic to drive in a restrained or considerate manner. While these measures are designed to prevent conflicts between pedestrians and motorists, they impose unstable traffic patterns and are sometimes unable to accommodate the increasing motor vehicle flows, as they are concentrated only on certain streets.
This paper investigates area-wide urban traffic calming techniques from existing projects. It explains how traffic regulatory and structural measures link together or separately to restrict the movement of motor vehicles traveling through neighborhood streets and divert them to main roads. The implemented sample measures were illustrated and described with photos of their current locations.
In this thesis, the district Äußere Neustadt was defined as a model area in Dresden to analyze and redesign the existing mobility plan in order to reduce the MIV flows with the main objectives of giving space for pedestrians, cyclists, and public transport. The district's street infrastructure is heavily impacted by the presence of parked vehicles, raising challenges to the safe movement of both bicyclists and oncoming motor vehicles. In the frame of the model project initiative - "Woche des guten Lebens", the volunteer team has designed a traffic experiment and carried out an online survey to assess citizens' opinions of the Äußere Neustadt. The analyses demonstrate and emphasize the necessity of political support and interactive communication with citizens regarding the area-wide radical sustainable mobility plan. Considering the positive feedback of the citizens, the new mobility plan was realized in this paper.
Area-specific traffic calming techniques such as diagonal or cross barriers, zone speed limits, offsets, one-way streets, etc. were analyzed from the implemented projects to determine the appropriate solutions for the specified streets. The district's existing traffic network and the new solutions offered were visualized using QGIS software.
The implemented new traffic plan will lead to more space for pedestrians and bicycle traffic and a reduction in traffic noise.
Objective: Sagittal balance (SB) plays important role in the successful treatment of spinal disorders. Segmental lordosis is an important SB parameter in spinal surgery and diagnosis, which can help to ensure proper surgical planning and better postoperative outcomes. The manual measurement of segmental lordosis is associated with problems such as time-consuming procedures, high error rates, and poor reproducibility.
The bachelor thesis proposes a solution by exploring and evaluating a more efficient and reliable AI-based method for determining segmental lordosis in preoperative patients, which is compared to measurements made by experienced physicians.
Methods: hidden due to a non-disclosure agreement.
Results: hidden due to a non-disclosure agreement.
Conclusions: hidden due to a non-disclosure agreement.
Between Clash of Civilizations and Global Identity - the Interdependence of Culture and Economics
(2019)
Our life is becoming faster, more connected and more global - this developments have a lot of positive but also negative effects. Being fearful towards the "different" is a growing phenomenon and the question arises of we heading towards a global identity or a clash of civilizations, which factors play the important parts and how did they come into existence. By using North African immigration in France as an example, an approach is made to put this topic in a smaller context in order to see where the scenario is heading to and what is conducive and/or detrimental.